Successful Use of AI Technology for Efficient Prediction of Physical Properties of Substances with Complex Molecular Structures
Press Releases • Sep 14, 2018 23:00 GMT
- The study demonstrated that machine learning can be applied to predict physical properties of functional materials that have complex structures. - For the first time in the world, machine learning methodology has been applied to the analysis of complex molecular structures of surfactants that are used in our immediate surroundings, such as detergents and cosmetic products.
Press Releases • Aug 24, 2018 14:00 GMT
Bleeding in the digestive system occurs when patients have ulcers, inflammation and cancers. Therefore, an early sign of such diseases may be microscopic blood in stool, which doctors refer to as “fecal occult blood” (FOB). The luminol reaction, which has been used in forensics to detect trace amounts of concealed blood, can also be applied for detection of FOB, according to Kindai University researchers, led by Ah-Mee Park, Ph.D, Associate Professor in the Department of Microbiology, Faculty of Medicine.
1.Experiments have shown that the luminol reaction can be used to detect FOB in animals.
2.This is the first standard method to detect FOB in animal models for ulcers and cancers in the digestive system - which is simple, quick, economical and quantitative - making it applicable to use for any research laboratories.
3.It is hoped these findings will contribute to the furthering of research on gastric ulcers and colon cancer.
FOB, or microscopic blood in the stool, is a sign of gastrointestinal diseases, such as intestinal ulcers and colon cancers. To discover the precise cause and new treatments for such diseases requires animal models, in which the levels of FOB are measured to assess the severity of gastrointestinal bleeding. Unlike in clinical human stool samples, however, there is no standard method to detect FOB in experimental animals.
Kindai University researchers present a simple method to detect FOB in mice, using the luminol reaction, which has been used to detect bloodstains at crime scenes, like those often seen in detective stories and TV shows. By mixing feces with a luminol solution, hemoglobin-containing fecal samples produce visible blue light (chemiluminescence). The levels of FOB are measured by the hemoglobin content; a higher content corresponding to a higher brightness level of the chemiluminescence - as measured by a luminometer. This method is simple, quick, economical, and quantitative, allowing researchers to detect FOB in experimental animals. The application of the luminol reaction in clinical medicine is expected to contribute to furthering disease research.
Ah-Mee Park and Ikuo Tsunoda, “Forensic luminol reaction for detecting fecal occult blood in experimental mice” is published in the British scientific journal, BioTechniques, August 2018(Impact factor 2.030)
Details of the research
Bloody stool samples were collected from mice with intestinal ulcers, which were induced by injection of indomethacin, a non-steroidal anti-inflammatory drug. Fecal samples were mixed with a luminol solution and observed in dark field. The blue chemiluminescence became detectable 4 hours after the injection, and the intensity of the chemiluminescence was measured by a luminometer. The levels of FOB were calculated by the ratios of the chemiluminescence intensities of fecal samples to the chemiluminescence intensity of a luminol solution alone.
To detect FOB in human stool, there are two standard methods; the stool guaiac test and the hemoglobin antibody immunochemical test. The guaiac test using the colorimetric method is easy to operate, but lacks quantification and can be affected by other factors. On the contrary, the immunochemical test is expensive, but allows quantification of the hemoglobin content, is specifically for hemoglobin and is not affected by other factors. On the other hand, for experimental animal studies, researchers often assess the FOB levels by stool color and appearance since there is no standard method to detect and quantify FOB in animals.
Outlook for the future
Since this FOB detection method is simple, quick, economical, and quantitative, most researchers in the field of gastrointestinal diseases can use it easily in their laboratories as a gold standard method, allowing for more precise assessment of their experimental results, as well as comparison of reports between different laboratories and scientific articles. The limitations of the luminol reaction applying to human stool samples include several factors that affect the reaction, for example, food or bleach. Nevertheless, this discovery will help advance the field of research in gastrointestinal diseases.
Profiles of Researchers
Name: Ah-Mee Park, Ph.D.
Affiliation: Dept. Microbiology, Kindai University Faculty of Medicine
Specialty: Microbiology, Free radicals
Metropolitan DC Thoracic Society Annual Meeting: First Prize
Annual Meeting of American Thoracic Society: Travel Award
1.Experiments have shown that the luminol reaction can be used to detect FOB in animals. 2.This is the first standard method to detect FOB in animal models for ulcers and cancers in the digestive system - which is simple, quick, economical and quantitative - making it applicable to use for any research laboratories.
Japanese High School Students Set the World as the Stage Proposing a Project for Contributing to Society -Entrepreneurship World Competition-
Press Releases • Aug 09, 2018 05:30 GMT
[Time and Date] August 8th - August 14th
[Location] Durban, South Africa
[Sponsored] SAGE Global
[Participated Countries] USA, Ukraine, Canada, Chile, China, India, Iran, Ireland, Nigeria, Korea, Russia, Pakistan, Australia, Japan, etc. Around 30 countries and regions
A domestic event held in March (sponsored by SAGE JAPAN CUP・Tokyo Metropolitan Government Board of Education etc.) the first place team H.O.P.E from Tokyo Metropolitan Kokusai High School will participate in the Sage World Cup held in South Africa.
SAGE was established in the United States of America in 2002, and this year will the 16th year of the World Cup and high school teams from around 30 countries and regions will participate this year. Japan will send a high school team for the third straight year. Two years ago at the Philippines World Cup, Tokyo Metropolitan Ryogoku High School represented Japan and last year at the Ukraine World Cup, Yokohama Science Frontier High School represented Japan. This year, Tokyo Metropolitan Kokusai High School will challenge themselves to make a presentation, aiming to claim the top prize.
During the World Cup, high schools from each country will participate in culture exchanges.
<Contact in regard to the event>
Professor Takeshi Miyazaki, Soka University: Iwaki
*For more information please visit the homepage
[Time and Date] August 8th - August 14th [Location] Durban, South Africa [Sponsored] SAGE Global [Participated Countries] USA, Ukraine, Canada, Chile, China, India, Iran, Ireland, Nigeria, Korea, Russia, Pakistan, Australia, Japan, etc. Around 30 countries and regions
World’s First Demonstration on Efficacy of Drug for Lung Cancer Genetic Mutation Diagnosed with Blood sample using cobas EGFR mutation test v2.Alleviating burden on patients through diagnosis with blood tests
Press Releases • Jul 31, 2018 07:09 GMT
[Key aspects of this study] - World’s first research findings that demonstrate efficacy and safety of a drug which is administered based on genetic screening results. - Efficacy demonstrated by a response rate of 55.1%, which represents the ratio of people whose tumor shrunk. - Potential for partial transition to blood test from endoscopic biopsy, which places a heavy burden on patients.
Ritsumeikan University to Establish the College of Global Liberal Arts in April 2019 on Osaka Ibaraki Campus
Press Releases • Jun 18, 2018 05:00 GMT
Ritsumeikan University will establish the College of Global Liberal Arts in April 2019, a new undergraduate dual degree program with The Australian National University to offer border-spanning Asia Pacific-centered liberal arts education for a global era.
Soka University is holding a Kickoff Symposium for MEXT's "Private University Research Branding Project" titled "Establishment of a Recycling-oriented Society in African Countries - Interdisciplinary Collaboration between Ethiopia and Japan -"
Press Releases • May 09, 2018 03:09 GMT
Soka University will hold a Kickoff Symposium entitled, "Establishment of a Recycling-oriented Society in African Countries - Interdisciplinary Collaboration with Ethiopia -" at Room 201, S Building, Soka University on 12th May (Sat).
Joined by 250 universities in 25 Countries and Regions worldwide, The Association of Southeast Asian Institutions of Higher Learning's (ASAIHL) annual conference will be held at Soka University - Held in Japan for the first time -
Press Releases • Mar 16, 2018 05:38 GMT
The 2018 ASAIHL Conference will be held from March 26th to March 28th (Supported by: MEXT, Hachioji City) at Soka University (Hachioji City, Tokyo / President: Yoshihisa Baba).
Bringing you the latest news - in English - from Japanese universities: "Japan University News" launches!
Press Releases • Mar 15, 2018 03:57 GMT
With the goal of increasing global awareness for Japanese universities as well as building a platform for pro-actively building relationships with international media, Daigaku Tsushin will commence "Japan University News" in April of 2018.
About Japan University News
“Japan University News” is an English-language news portal that provides an outlet for the latest news of Japanese Universities for a global audience. It provides an overview of the unique culture, prominent research and contributions to the global society of Japanese Universities for international media, stakeholders and other interested parties.