Categories: kindai university
Treating Autoimmune Pancreatitis Without Steroids: Researchers Develop Novel Approach
Autoimmune pancreatitis (AIP) is usually treated with steroids, which may cause severe side effects. Now, researchers from Japan suggest that the selective activation of the transcription factor - aryl hydrocarbon receptor (AhR) - could inhibit the development of AIP with minimal side effects.
First time selling of aosa miso soup with Kindai tuna backbone broth in the U.S.: To be introduced at the Wakayama Fair in Hawaii and California -- Kindai University
- First time selling of “aosa miso soup with Kindai tuna backbone extract” overseas - Selected as a local specialty product to be introduced at the Wakayama Fair in multiple markets in the United States
First report of quantitative analysis on the number of strawberry powdery mildew conidia produced in a lifetime -- Hopes of suppressing powdery mildew fungi without over-reliance on agricultural chemicals -- Kindai University
- Analyzed the number of progeny conidia dispersed in a lifetime from a single strawberry powdery mildew colony - Revealed that the releases of progeny conidia from the colonies are affected by the day length and light intensity - These results could connect to a new method of disease controls that are independent of agricultural chemicals
Indicator molecule determined for mitochondrial toxicity arising from side effects of medicine -- High hopes of application to a new method of toxicity assessment in drug development -- Kindai University
- Conducted metabolomic analysis on human hepatoma cell lines which were exposed to mitochondrial toxic compounds - Utilized bioinformatics to identify the indicator molecule which determines the mechanism of mitochondrial toxicity - These results could be applied to a new toxicity assessment method in the drug development field
First report of a begomovirus species infecting tomato plants in Okinawa -- Virus invasion from overseas poses a threat to tomato production across Japan -- Kindai University
- A species of begomovirus yet to be reported in Japan has been identified in Okinawa-grown tomatoes - The newly identified begomovirus is prone to cause disease in virus-resistant tomatoes - The study alerts for the invasion of foreign viruses to the tomato producing areas across Japan
Elucidation of pathogenesis of ulcerative colitis and Crohn’s disease: Leading to new treatment methods for refractory inflammatory bowel diseases -- Kindai University
- The team discovered that type I interferon, one of the inflammatory cytokines, is involved in exacerbation of inflammatory bowel disease. - An enzyme that inhibits the activity of type I interferons has been identified as a novel therapeutic target for inflammatory bowel disease. - This research offers insights into the development of new treatments for intractable inflammatory bowel disease.
Revealing the mechanism of immunity activation by extracellular vesicles from lactobacillus: Leading to deep understanding of the bacteria in our daily food and insights into better intestinal environment -- Kindai University
Elucidated the mechanism of immune cell activation by extracellular vesicles of lactobacillus Identified outer surface proteins of extracellular vesicles that affect immune activation The findings of this research will lead to the development of technologies to improve intestinal environment and to maintain healthy physical functions.
Finding the source of pathogen infectivity in rice to reveal the mechanism of induction of immunity:A new insight into the development of disease-resistant plants -- Kindai University
Discovered a transcription factor called “OsERF101” that plays an important role in rice immunity Elucidated the mechanism by which rice pathogen recognition receptor activates immunity by recognizing the most important virulence factors of the pathogens. Expected that this research will contribute to a new development of disease-resistant plants.
World’s first! Identified pathogenic bacteria for autoimmune pancreatitis: A healthy intestinal environment may help prevent and treat autoimmune pancreatitis -- Kindai University
Discovered that intestinal barrier dysfunction exacerbates autoimmune pancreatitis The pathogenic bacterium of autoimmune pancreatitis, an intractable disease, was identified as an intestinal bacterium, Staphylococcus sciuri Suggested that maintenance of a healthy intestinal environment may lead to the prevention and treatment of autoimmune pancreatitis
A new program to classify solid tumors into eight genomic subtypes: Leading to predictive response analysis for cancer tumor ICI efficacy -- Kindai University
- Analyzing DNA data of approximately 10,000 cases, the team developed a new program to classify solid tumors into eight genomic subtypes - Demonstrated that these eight classifications were significantly associated with ICI efficacy - The results of this study will help predict response to ICI therapy on solid tumors and improve prognosis
Novel research on bacteria and fungi on face masks promotes the hygienic use of masks under the COVID-19 pandemic -- Kindai University
- The first research focused on the usage of masks and bacteria and fungi attached to the face-side and the outer-side of masks -Recommended avoiding repeated use of masks (no more than one day) for people with weak immunity since potentially harmful microbes were found -This study will provide new insights into the appropriate and hygienic use of face masks under the COVID-19 pandemic.
Contributing to lightning disaster prevention in Malaysia -- Selected for the FY2022 Science and Technology Research Partnership for Sustainable Development (SATREPS) Program
Our joint research on lightning disaster prevention has been selected for SATREPS Promoting this research in collaboration with ODA. Real-time 3D imaging of charge distribution in thunderclouds and forecasting of lightning activity based on the observation technology cultivated over the years, it aims to prevent and mitigate disaster in Malaysia where the annual lightning day exceeds 200 days.
Discovered “GT-7” compound induces cell death in pancreatic cancer cells - Expected for a new treatment approach different from the mechanisms of conventional anticancer drugs
Found that GT-7 induces apoptosis of pancreatic cancer cells with specific gene mutations.
Curcumin prodrug CMG has beneficial effects on a mouse model of multiple sclerosis by modulating the gut flora -- Kindai University
CMG treatment for a mouse model of multiple sclerosis (MS) suppressed motor paralysis clinically and inflammation in the central nervous system (CNS) microscopically. CMG treatment altered the gut flora in the intestine and feces. Increases in several bacterial species correlated with the disease severity.
Functional bag “Peg” created through industry-academia cooperation to be launched in New York. Contributes to the recovery and promote SDGs with shark leather from Kesennuma, Miyagi, Japan
- Kindai University students and a leather brand "Atelier Shark" jointly developed a small functional bag that is useful in outdoor environments and in the event of disaster. The bags will be released in New York. - Lightweight blue shark leather from Kesennuma City, Miyagi, has excellent drip-proof and durability. Disseminating the benefits of the shark leather supports the reconstruction and ind
World-first research: bringing more insights into biodiversity -- A new technique to analyze genomic functions of wild and extinct animals -- Kindai University
Developed a new method that induces the reprogramming of the mammalian genome, including wild/endangered species, and induces the activation of genes that are specifically expressed in early embryos. The result brings insights into biodiversity, allowing analysis of genomic functions of extinct animals.
Next-generation prebiotic promotes selective growth of beneficial bacteria -- Paving the way for new treatments for refractory clostridioides difficile colitis -- Kindai University
Discovered that Galactosyl-β1, 4-L-Rhamnose (oligosaccharide) selectively promotes the growth of health-promoting bacteria. Identified the gene required for the growth promotion specific to bifidobacteria, utilizing oligosaccharide.
PCR Test Center Launches at Kansai International Airport, Enabling 3-Hour Issuance of Negative Result Certificates -- Kindai University
Kindai University Kansai International Airport Clinic and Kawasaki will launch a PCR test center at Kansai International Airport on September 22, 2021.
Developed a novel, “Soft Rubber Bolus” for radiation therapy - Easily shapable by hand, leading to high-precision irradiation and more adapted treatment -- Kindai University
- Enables shape adjustment on site during treatment which was impossible with conventional tools - Achieves close fitting on uneven parts by shaping easily with heating. Allows for more personalized radiation therapy - Can be disinfected and reused, and easily utilized at multiple medical institutions