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Alyref and Gabpb1 -- Gene Targets to Overcome Preimplantation Arrest in Cloned Embryos Discovered -- Kindai University

Alyref and Gabpb1 -- Gene Targets to Overcome Preimplantation Arrest in Cloned Embryos Discovered -- Kindai University

Japanese scientists have now discovered the specific genes responsible for this phenomenon. Their findings show that the incomplete activation of the Alyref and Gabpb1 genes causes early embryonic arrest, while the supplementation of these genes supports normal embryonic growth. These findings could guide genetic manipulation strategies to optimize animal cloning.

Human FUS Protein Suppresses the Production of Toxic Repeat Polypeptides that Cause Neurodegenerative Diseases -- Kindai University

Human FUS Protein Suppresses the Production of Toxic Repeat Polypeptides that Cause Neurodegenerative Diseases -- Kindai University

Now, Japanese researchers have discovered a key regulatory mechanism involved in C9orf72-linked amyotrophic lateral sclerosis (ALS)/ frontotemporal dementia (FTD) (C9-ALS/FTD). Their findings indicate that in C9-ALS/FTD, the human FUS protein can interact with RNAs containing GGGGCC repeats and suppress their translation by altering their three-dimensional structures, inhibiting neurodegeneration.

Elucidating the Mechanism of Aldosterone Overproduction by Adenomas Presents Novel Hypertension Drug Target -- Kindai University

Elucidating the Mechanism of Aldosterone Overproduction by Adenomas Presents Novel Hypertension Drug Target -- Kindai University

Now, a global consortium of researchers has pinpointed that non-inheritable mutations within the cell adhesion molecule 1 (CADM1) gene of these "aldosterone-producing adenomas (APAs)" inhibit communication between aldosterone-producing cells, resulting in hormonal overproduction. These findings provide a potent new target for the development of drugs to treat hypertension caused by APAs.

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