Elucidation of the role of "Stress Granules" that can be therapeutic targets for cancer and ALS -- Kindai University
- Discovered for the first time in the world that Stress Granules (SGs) have the role of a "safety brake" that regulates signaling pathways that control cell proliferation, such as Protein Kinase C (PKC) and Mitogen-Activated Protein Kinase (MAPK). - SGs have the function of preventing excessive activation of MAPK by incorporating PKC.
Mechanism of the selective induction of cancer cell-specific cell death by ACA-28 - Kindai University
- Elucidation of the mechanism of the compound "ACA-28" that selectively induces cell death in cancer cells - ACA-28 induces cell death of cancer cells and inhibits the growth by destroying tumor suppressor factors. - Expectations for the development of anticancer drugs with less side effects that target brakes instead of accelerators for cancer cells
Efficacy of Esophageal Cancer Postoperative Adjuvant Treatment, Peptide Vaccine Treatment, Elucidated 5-year Survival Rate Approx. Doubled for Esophageal Cancer Patients - Kindai University
Kindai University’s Faculty of Medicine has, in a world first, shown the efficacy of cancer-specific vaccine therapy as a postoperative adjuvant therapy in a phase 2 clinical trial. Administration of cancer-specific vaccine therapy roughly doubled the 5-year survival rate of advanced esophageal cancer patients. Vaccine therapy amplifying CTL2 is expected to help validate peptide vaccine therapy.