Alyref and Gabpb1 -- Gene Targets to Overcome Preimplantation Arrest in Cloned Embryos Discovered -- Kindai University
Japanese scientists have now discovered the specific genes responsible for this phenomenon. Their findings show that the incomplete activation of the Alyref and Gabpb1 genes causes early embryonic arrest, while the supplementation of these genes supports normal embryonic growth. These findings could guide genetic manipulation strategies to optimize animal cloning.
Possible Existence of Earth-Like Planet Predicted in the Outskirts of the Solar System -- Kindai University
Now, based on detailed computer simulations of the early outer solar system, researchers from Japan predict the possibility of an undiscovered Earth-like planet beyond Neptune orbiting the Sun. Should this prediction come true, it could revolutionize our understanding of the history of the solar system.
Human FUS Protein Suppresses the Production of Toxic Repeat Polypeptides that Cause Neurodegenerative Diseases -- Kindai University
Now, Japanese researchers have discovered a key regulatory mechanism involved in C9orf72-linked amyotrophic lateral sclerosis (ALS)/ frontotemporal dementia (FTD) (C9-ALS/FTD). Their findings indicate that in C9-ALS/FTD, the human FUS protein can interact with RNAs containing GGGGCC repeats and suppress their translation by altering their three-dimensional structures, inhibiting neurodegeneration.
Elucidating the Mechanism of Aldosterone Overproduction by Adenomas Presents Novel Hypertension Drug Target -- Kindai University
Now, a global consortium of researchers has pinpointed that non-inheritable mutations within the cell adhesion molecule 1 (CADM1) gene of these "aldosterone-producing adenomas (APAs)" inhibit communication between aldosterone-producing cells, resulting in hormonal overproduction. These findings provide a potent new target for the development of drugs to treat hypertension caused by APAs.
Barcoding Invisible Life: Detection of Arthropods Using Environmental DNA Collected from Plant Runoff -- Kindai University
A team of researchers from Japan has recently developed a non-destructive ‘metabarcoding’ method for collecting the environmental DNA of terrestrial arthropod communities from water flowing over plant surfaces, which could revolutionize how we document terrestrial arthropods.
New Study Sheds Light on Chemotherapy Resistance in Pancreatic Cancer Cells for Improved Therapeutics -- Kindai University
Advanced pancreatic cancer is typically treated with chemotherapeutic drugs like gemcitabine. However, resistance to these drugs over time may result in treatment failure. Researchers from Japan have now revealed the genetic mechanisms behind this drug resistance.
Treating Autoimmune Pancreatitis Without Steroids: Researchers Develop Novel Approach
Autoimmune pancreatitis (AIP) is usually treated with steroids, which may cause severe side effects. Now, researchers from Japan suggest that the selective activation of the transcription factor - aryl hydrocarbon receptor (AhR) - could inhibit the development of AIP with minimal side effects.
First time selling of aosa miso soup with Kindai tuna backbone broth in the U.S.: To be introduced at the Wakayama Fair in Hawaii and California -- Kindai University
- First time selling of “aosa miso soup with Kindai tuna backbone extract” overseas - Selected as a local specialty product to be introduced at the Wakayama Fair in multiple markets in the United States
First report of quantitative analysis on the number of strawberry powdery mildew conidia produced in a lifetime -- Hopes of suppressing powdery mildew fungi without over-reliance on agricultural chemicals -- Kindai University
- Analyzed the number of progeny conidia dispersed in a lifetime from a single strawberry powdery mildew colony - Revealed that the releases of progeny conidia from the colonies are affected by the day length and light intensity - These results could connect to a new method of disease controls that are independent of agricultural chemicals
Indicator molecule determined for mitochondrial toxicity arising from side effects of medicine -- High hopes of application to a new method of toxicity assessment in drug development -- Kindai University
- Conducted metabolomic analysis on human hepatoma cell lines which were exposed to mitochondrial toxic compounds - Utilized bioinformatics to identify the indicator molecule which determines the mechanism of mitochondrial toxicity - These results could be applied to a new toxicity assessment method in the drug development field
First report of a begomovirus species infecting tomato plants in Okinawa -- Virus invasion from overseas poses a threat to tomato production across Japan -- Kindai University
- A species of begomovirus yet to be reported in Japan has been identified in Okinawa-grown tomatoes - The newly identified begomovirus is prone to cause disease in virus-resistant tomatoes - The study alerts for the invasion of foreign viruses to the tomato producing areas across Japan
Elucidation of pathogenesis of ulcerative colitis and Crohn’s disease: Leading to new treatment methods for refractory inflammatory bowel diseases -- Kindai University
- The team discovered that type I interferon, one of the inflammatory cytokines, is involved in exacerbation of inflammatory bowel disease. - An enzyme that inhibits the activity of type I interferons has been identified as a novel therapeutic target for inflammatory bowel disease. - This research offers insights into the development of new treatments for intractable inflammatory bowel disease.